16 bit ISA slots are 80’s technology and today’s major computer
manufacturers don’t make computers with ISA slots.

What do you do if you have a CNC router to maintain or you have
machinery worth millions of dollars to maintain? You call niche vendors
like Interloper.com. They maintain a sizeable inventory of computers and
motherboards with ISA slots – from the really old 385 / 486 motherboards
to the more modern Pentium 4 socket 478 and socket 775 motherboards.
 

Form factor is another issue you may face. Some routers and
manufacturing machinery use the Baby AT style motherboards, some use ATX
while others Micro ATX. It becomes a challenge but what to do – you have
a machine to keep running and if it requires a computer with ISA slots,
then that is what you get. Call Interloper.com if you need help in this
area.
 

Newer modern routers and machinery use PCI slots so they have less of
a worry, at least for now computers still come with one or two PCI slots
but in a few years, they may fall by the wayside like ISA.
 

Happy tooling!